However, the molecular mechanism of Pterocarpus marsupium has not been investigated. An aqueous extract of Pterocarpus marsupium … The Laboratory Experiments conducted by Modern Institutes has concluded that Pterocarpus Marsupium decreased the blood glucose levels both in normal and non-insulin dependent diabetic rats. A list of medicinal plants with proven antidiabetic and related beneficial effects and of herbal drugs used in treatment of diabetes is compiled. Botanical Name of Pterocarpus : Pterocarpus marsupium Family : Fabaceae Synonyms of Pterocarpus: Hindi - Vijaisar kaashtha English - Indian kinowood Sanskrit - Pitasala Asana, … pharmaceutical treatments for diabetes. Pterocarpus Marsupium in Deutsch ist für die Behandlung von Diabetes, Diabetes, Hyperglykämie und anderen Bedingungen. (2000) Pterocar-, Anandharajan R, Pathmanathan K, Shankernar, extracts on clinical and standards strains of, Majeed M, Bani S, Natarajan S, Pandey A (2017) E, Track the below URL for one-step submission, https://juniperpublishers.com/online-submission.php. These studies play the drug as a novel candidate for bioprospection and drug development for treatment of diseases such as cancer, diabetes, cataract, ulcer, dementia… Bijayasaline (1) showed potent DPPH free radical scavenging activity. Rising popularity of phytomedicines in various diseased conditions have strengthened the significance of plant-research and evaluation of phytoextracts in clinical manifestations. was to assess the hypoglycemic effect of the ethanolic extract of Pterocarpus marsupium seeds in diabetic rats.Methods: The present work was designed to evaluate the anti-hyperglycaemic activity of Pterocarpus marsupium seed extract (100 mg/kg and 200 mg/kg) on gabapentin induced hyperglycaemia in wistar albino rats. 9Æïh|Åï›ÈÞcþÑOL~)ڝÈ?±ú›Î¿îý8ΰ™2õ¸à.#z’­èàí6ª¹JÝ 8cz“¯ìð݋ì5.ÑB.G"$¹áa.ÆƇü4E¸]¾øµ>킂‚J`Ð Rª€ˆt ”)©w ª"0 difficult in near future for use in Indian system of medicine. Pterocarpus marsupium reduces blood sugar level, cholesterol and triglycerides. Detaillierte Informationen im Zusammenhang mit … The rats were divided into five groups, each having six rats. Good amount of total phenolics and total flavonoids in small branches and HPTLC profile with many bands indicates that small branches may also have potential active constituents and may be studied for various pharmacological activities. Pterocarpus marsupium (Roxb.) So work is carried out to establish preliminary physicochemical and phytochemical standards of small branches of P. marsupium. Pterocarpus Marsupium is used for Diabetes, Hyperglycemia and other conditions. Despite many proposed therapeutic applications, the safety profile of 3'-HPT has not been established. Results showed no significant differences in body weight, food intake, absolute organ weight, haematology, with no adverse effects (toxicity) on biochemical values nor any abnormal clinical signs or behavioural changes were observed in any of the control/treatment groups, including reproductive and developmental parameters, gross and histopathological changes. The aim of the study was to evaluate the effect of Pterocarpus marsupium (PM) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. Pterocarpus marsupium Roxb., is a deciduous tree commonly grows in Sri Lanka and India [1]. The leaves are often applied externally as a remedy for skin diseases. Vijaysar is an important herb mentioned in Ayurveda for its healing properties especially for its ability to heal diabetes. Termed biologically as Pterocarpus marsupium… Literature suggests that Pterocarpus marsupium is useful in treating leprosy, skin diseases, diarrhoea, asthma, bronchitis, grayness of hairs, and other common problems. History showed that medicinal plants have been used in traditional healing around the world for a long time to treat diabetes; this is because such herbal plants have hypoglycemic properties and other beneficial properties, as reported in scientific literature. This work is an attempt to evaluate the possibilities of using small branches in place of heart wood. Diabetes: Holy basil might lower blood sugar levels. The phytoextract also exhibited high phenolic and flavonoid contents with promising antioxidant potential against the antioxidant assays evaluated. One of the most important benefits of Vijaysar tree or Pterocarpus Marsupium is to control diabetes. The Pterocarpus marsupium carried out an importance from the ancient times to cure mankind against various disease conditions. UC was induced by administering AA (3 % v/v of 2 ml) to all the animals except group one. In conclusion, the results suggested a No-Observed-Adverse-Effect-Level (NOAEL) of 200 mg/kg bwt/day in rats after oral administration, implying 3'-HPT did not exhibit any toxicity under the study conditions employed. ãFQ†0††{L™"^Ež3±±¨1j3–1. Uses : The heartwood of pterocarpus marsupium is astringent, bitter acrid, anti inflammatory, anthelmintic and anodyne. Two fractions (2.5% and 5%) of extract from the medicinal plant Pterocarpus marsupium … Diabetes mellitus (DM), both insulin-dependent DM (IDDM) and non-insulin dependent DM (NIDDM) is a common and serious metabolic disorder throughout the world. Pterocarpus marsupium may lower blood sugar through an unrelated pathway of that of insulin. heartwood in alloxan induced diabetic rats using extracts obtained by optimized conventional and non conventional extraction methods. Buy Panchaveda Pterocarpus Marsupium 400 mg Extract (120 Veg Capsules) Organic Natural Ayurvedic Herbal Diabetes Blood Sugar Support Supplement, Vijaysar Indian Kino Tree Helps Bad … Detailed information related to Pterocarpus Marsupium… The alcoholic extract of P. marsupium across varying concentrations showed inhibitory effect as evident by IC50 on advanced glycation-end-products formation (55.39 μg/ml), sorbitol accumulation (151.00 μg/ml) and rat kidney aldose reductase (195.88 μg/ml). It seems that there are different cellular binding sites for insulin and Pterocarpus marsupium, which … The present paper is an attempt to list of the plants with anti-diabetic and related beneficial effects originating from different parts of world. It is considered magical for diabetes. The heartwood extract of P. marsupium … Cytokine TNF-… Among many medications and other alternative medicines, several herbs have been known to cure and control diabetes; additionally they have no side effects. Some of these herbal plants and their active chemical constituents which have a role in the management of diabetes mellitus are compiled here and discussed in this review. It is well known to Ayurvedic medicine because of its curative and lenitive properties. A new C-glucosyl-alpha-hydroxydihydrochalcone derivative, (aS)-3'-C-ff-glucopyranosyl-a,3,4,2'4'-pentahydroxydihydrochalcone, named as bijayasaline (1) was isolated from the heartwood of Bijayasal (Pterocarpus marsupium) and characterized on the basis of NMR and circular dichroism (CD) spectral data. It is … Group two served as UC control animals, and group one control animals received vehicle for 7 days. Aqueous extract of the wood of this plant has a long history to be used in treatment of diabetes mellitus. Our ancestors used the barks and heartwood of Vijaysar tree in various forms to control diabetes. The present work investigated 90 day repeated oral dose and reproductive (developmental) toxicity of 3'-HPT as a test substance in rats as per OECD guidelines. Also the phytoextract at the concentration of 10–320 μg/ml was evaluated for its antioxidant potential by in-vitro antioxidant assays which includes, determination of total phenol content; reducing power assay; nitric oxide scavenging activity; superoxide radical scavenging activity; total antioxidant capacity; total flavonoid content; DPPH scavenging activity; and hydrogen peroxide scavenging activity.  , Bose SN, Sepaha GC (1956) Clinical observations on the antidiabetic, against carbon tetrachloride induced dam-, Hilal A, Kalyanaraman R (2015) Pharmacology of, Pradhan S, Sahu SK, Panda SK, Mishra SS, Chinar, by LC–MS techniques and its in-vitro lipid lowering activity, Haranath PS, Ranganatha Rao K, Anjaneyulu CR, Ramanathan JD,          , Jain SC, Sharma SK, Kumar R, Rajwanshi VK, Babu BR (1997) A homoi-, Handa SS, Singh R, Maurya R, Satti NK, Suri KA, et al. Heart wood and small branches of P. marsupium are compared on the basis of physicochemical analysis, phytochemical analysis and high performance thin layer chromatography (HPTLC). This review addresses the experimentally authenticated facts and also suggests the need for research on chemical and pharmacological properties of Pterocarpus marsupium. in a neonatal rat model. Vijaysar benefits in ayurveda are vast, such as treating diabetes by preventing damage to pancreatic cells, improving digestion and enriching skin texture. The 200 mg/kg had more pronounced effect on postprandial hyperglycemia. International Journal of Pharmacy and Pharmaceutical Sciences, Research Journal of Pharmacognosy and Phytochemistry. The medicinal plants, besides having natural therapeutic values against various diseases and considerable works have been done on these plants to treat diabetes mellitus, describes that the antidiabetic activity of medicinal plants is due to the presence of phenolic compounds, flavonoids, terpenoids, coumarins and other constituents which show reduction in blood glucose levels. These include, Allium sativum, Eugenia jambolana, Momordica charantia Ocimum sanctum, Phyllanthus amarus, Pterocarpus marsupium… 3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium. Difference in HPTLC profiles suggests that small branches cannot be used in place of heart wood and further research is required to find out the substitute for heart wood of P. marsupium. Water is kept in the wooden glass of its bark overnight and that water is consumed by diabetes … It also lowers the symptoms of diabetes such as frequent urination, over eating, regular thirsts, and burning pains in limbs. (family Fabaceae) is widely used as a traditional medicine to treat various diseases, including diabetes. PM (100 and 200 mg/kg)-treated group had significantly reduced colon inflammation and mucosal damage. Long-term complications are frequently encountered in diabetes mellitus and are difficult to treat. Treatment of Diabetes: As discussed above, one of the most popular ways in which Pterocarpus marsupium … Pterocarpus marsupium and diabetes control is a viable alternative used by Indians for centuries to improve the pathological process related to the liver, skeletal muscles, and pancreatic islets that are … Šw ˆ3½‚“ ‰Z ên´”’a`ù HÛ V,Ë ÀÀÁäÅ ÄPÏPÇPŸ‹)˜q Phytochemical analysis of heartwood and small branches showed the presence of phenols, tannins, alkaloids, carbohydrates, saponins, proteins, steroids, flavanoids, coumarin, quinine and furanoids in various extracts tested. The conditions commonly treated by pterocarpus in the Ayurveda system include diabetes, inflammation and bleeding. Pterocarpus marsupium Roxb., a medicinal plant, known for its anti-oxidant and anti-diabetic activity is a rich source of phytochemicals with antihyperglycemic and antihyperlipidemic activities. Pterocarpus marsupium showed a highly significant increase in serum ALP and ACP was noticed after 7 and 14 days of diabetes induction. Vijaysar, Malabar kino (Pterocarpus marsupium) - Properties, Benefits, Dosage Vijaysar is an important big tree whose bark is very useful in disease like diabetes. This might interfere with controlling blood sugar levels. It is now considered as a valuable source of unique natural products for development of medicines against various diseases and for the development of industrial products. Pterocarpus marsupium is a medicinal plant used in Ayurvedic system of medicine to control blood sugar and strong antidiabetic. The present investigation suggests that the phytoextract showed prominent antioxidant, antiglycation property and, inhibited accumulation of sorbitol and ALR enzyme, thus promising a beneficial role in reducing/delaying diabetic complications. A REVIEW-PHYTOMEDICINES USED IN TREATMENT OF DIABETES, Evaluation of 90 day repeated dose oral toxicity and reproductive/developmental toxicity of 3'-hydroxypterostilbene in experimental animals, Evaluation of effect of alcoholic extract of heartwood of Pterocarpus marsupium on in vitro antioxidant, anti-glycation, sorbitol accumulation and inhibition of aldose reductase activity, Phytochemistry and pharmacological activities of Pterocarpus marsupium: a review, Pharmacology of Pterocarpus marsupium Roxb, Evaluation of the protective effect of Pterocarpus marsupium on acetic acid-induced ulcerative colitis in rats, Bijayasaline: A New C-Glucosyl--hydroxydihydrochalcone from the Heartwood of Bijayasal (Pterocarpus marsupium), Hypoglycaemic effect of Pterocarpus marsupium, A Study on Hypoglycemic properties of Pterocarpus marsupium Roxb, Pterocarpus marsupium: A valuable medicinal plant in diabetes management, Hypolipidemic activity of Pterocarpus marsupium in streptozotocin induced diabetes, Antidiabetic effect of Pterocarpus marsupium seed extract in gabapentin induced diabetic rats, In vitro evaluation of antibacterial activity of pterocarpus marsupium roxb. 12 The heartwood is used in the treatment of inflammation and reported to have medicinal importance in the management of diabetes … Panchaveda Pterocarpus Marsupium 400 mg Extract (120 Veg Capsules) Organic Natural Ayurvedic Herbal Diabetes Blood Sugar Support Supplement, Vijaysar Indian Kino Tree Helps Bad Cholesterol … However, its possible role in diabetic complications is not evaluated yet. Total phenolic contents of heart wood and small branches in terms of tannic acid equivalent were 36.65±0.90 and 41.91±1.05 mg/g, respectively and total flavonoid contents in terms of querecetin equivalent were 56.30±0.38 and 70.22±1.25 mg/g, respectively. Study will be helpful in the identification and quality control of P. marsupium and can provide standard HPTLC profiles of P. marsupium with selected solvent system for use as a reference for the proper identification/authentication of the drug. HPTLC of n-hexane, ethyl acetate and ethanol extracts of heart wood and small branches showed different phytochemical profile. This study was undertaken to assess the effect of three antidiabetic plants on the development of cataract in rats. The plant Pterocarpus marsupium Roxb., belonging to the family Leguminosae commonly grows in the hilly regions of central and peninsular India. The results of the test drug were compared with the standard drug.Results: Ethanolic seed extract of Pterocarpus marsupium at 100 mg/kg and 200 mg/kg had significantly reduced the blood glucose level compared to disease control rats on day 1, 7, 14 and 21. The herb improved the body weight of diabetic animals. The standard parameters of small branches of P. marsupium have not been prepared yet. The present study explores the possible role of alcoholic extract of heartwood of P. marsupium in the treatment of long-term diabetic complications. The bark is also used for bleeding and toothaches. It is also considered as a potential source of drugs used as an anti-inflammatory, nootropic, astringent, anthelmintic, hypolipidemic, hepatoprotective, anti-ulcer, antioxidant, cardiotonic activities. Pterocarpus marsupium contain acids that reduce intestinal absorption of glucose, stimulate the pancreas to increase insulin production, and decrease sugar craving by causing sugar to taste like grit or sandpaper. Pterocarpus marsupium shows significant decrease in triglycerides levels, serum cholesterol levels, LDL levels and increased HDL levels, total protein levels compared to the disease control group.Conclusions: In conclusion, the present study shows that the ethanolic seed extract of Pterocarpus marsupium has potential antidiabetic action in gabapentin induced diabetic rats and the effect was found to be more similar to the standard drug metformin. Blood glucose level, serum triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol were evaluated in gabapentin induced diabetic rats. Aqueous extract of P. marsupium at doses 100 and 200 mg/kg, decreased the fasting and postprandial blood glucose in type 2 diabetic rats. Traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. Vijaysar continues to be used for diabetics … Pterocarpus marsupium Roxb., a medicinal plant, known for its anti-oxidant and anti-diabetic activity is a rich source of phytochemicals with antihyperglycemic and antihyperlipidemic … Anti-diabetic activity wasevaluated on experimental model byDelhi Institute of Pharmaceutical Sciences and Research (DIPSAR). After 72 h, the animals were killed and the colon was dissected out for microscopic, clinical evaluation, histopathological study and biochemical estimation. This essay details the vijaysar uses for health, formulations, dosage and side effects. The aim of the present study was to assess the anti-diabetic activity of Pterocarpus marsupium Roxb. Histopathological studies support the effect. Pterocarpus marsupium Roxb., is a deciduous tree commonly grows in India and Sri Lanka. According to a new study, an exotic Indian plant that's been used for centuries in Ayurvedic medicine can lower blood sugar in those with diabetes -- without side effects. The alcoholic extract of P. marsupium was evaluated for advanced glycation-end-products formation, erythrocyte sorbitol accumulation and rat kidney aldose reductase enzyme inhibition at the concentration of 25–400 μg/ml using in-vitro bioassays. For the reproductive toxicity study forty Wistar rats of each sex (80 rats) divided into four dosage groups received 0 (vehicle control), 20 (low dose), 100 (mid dose) and 200 (high dose) mg/kg bwt/day of 3'-HPT respectively for a period of two weeks while pre-mating, mating, on the day before sacrifice, in females during pregnancy and four days of lactation period.
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